Research on the Location Selection and Path Optimization of Pharmaceutical Distribution Centers Considering Supply Chain Resilience

Weijie Zhong; Si Zhang

doi:10.54097/9aq70468

Authors

Weijie Zhong
Si Zhang

DOI:

https://doi.org/10.54097/9aq70468

Keywords:

Dual objective optimization, Supply chain resilience, Pharmaceutical transportation, NSGA-II Algorithm

Abstract

This study explores the location-routing optimization for pharmaceutical cold chain distribution, addressing the challenges of supply stability and efficiency. A dual-objective model minimizing cost and time is proposed, incorporating supply chain resilience. An improved NSGA-II algorithm based on multiverse theory enhances solution quality and convergence. Using real data from South China, the study analyzes distribution center resilience and reveals trade-offs via Hyper Volume analysis. The findings support practical decision-making and enhance supply chain reliability.

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References

[1] Yin Y. Research on the Traceability Model of the Pharmaceutical Supply Chain Based on Blockchain Technology [J]. Economic Research Guide, 2023, (03):80-83.

[2] Xiang Xu, Fen Li, Ting Wu, Xinru Huang, Xueling Guan, Tingyu Zheng, Liang Shen. Location-routing optimization problem of pharmaceutical cold chain logistics with oil-electric mixed fleets under uncertainties[J]. Computers & Industrial Engineering, 2025, 201: 110932.

[3] Yuan Rong, Liying Yu, Yi Liu, Vladimir Simic, Dragan Pamucar. A pharmaceutical cold-chain logistics service quality model using a q-rung orthopair fuzzy framework with distance measure[J]. Engineering Applications of Artificial Intelligence, 2024, 136(B): 109019.

[4] Seung Jae Lee, Byung Soo Kim. Vehicle routing and scheduling problem with order acceptance for pharmaceutical refrigerated logistics[J]. Applied Soft Computing, 2024, 164: 111983.

[5] Aura Jalal, Eli Angela Vitor Toso, Reinaldo Morabito. A location– transportation problem under demand uncertainty for a pharmaceutical network in Brazil[J]. Computers & Chemical Engineering, 2023, 174: 108233.

[6] Zhang Y. Research on Risk Analysis and Response Strategies for Disruptions in the Pharmaceutical Supply Chain [J]. Logistics Technology, 2022,45(07):132-134.

[7] Hou F. Research on the Vegetable Distribution Route Planning of Company S Applying Circular Packaging Boxes [D]. Beijing Jiaotong University, 2019.